With Cardinal Orsini’s assassin in custody, Cesare Borgia plots to ensure the man’s loyalty but Cardinal Della Rovere isn’t so sure that the man knows nothing and also seeks his loyalty. The Cardinal soon organizes those who voted against the Pope and searches for a legal means to dethrone the him For his part, the Pope installs a new mistress, Giulia Farnese, in Orsini’s palace. The Pope’s 14 year-old daughter Lucrezia tells her mother of Giulia’s presence in the Papal rooms leading to a major confrontation. It may also provide Della Rovere what he needs to depose him. The Pope moves to neutralize Della Rovere and announces the appointment of 13 new Cardinals, including his son Cesare.